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KMID : 0361020070500040319
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Korean Journal of Otolaryngology - Head and Neck Surgery
2007 Volume.50 No. 4 p.319 ~ p.326
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Expression of S100A4 and S100A2 is Associated with Clinicopathologic Features in Papillary Thyroid Carcinoma
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Jung Eun-Jung
Hah Jeong-Hun
Jung Young-Ho
Kim Sang-Wook
Kwon Tack-Kyun
Sung Myung-Whun
Kim Kwang-Hyun
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Abstract
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Background & Objectives: S100 calcium-binding proteins are known to play multiple roles in progression and invasion of various carcinomas. In this study, we focused on two kinds of these proteins, S100A4 and S100A2, and investigated their expressions in thyroid neoplasm.
Subjects & Methods: We investigated S100A4 and S100A2 expressions in 75 thyroid neoplasms by immunohistochemistry.
Results: S100A4 and S100A2 were not expressed in normal thyroid follicles or follicular carcinomas. Positive relationships were established between S100A4 expression and size (p=.014), invasiveness (p=.029) and T stage (p=.004) of papillary carcinomas. Especially, the S100A4 expression was observed more frequently in the peripheral area (p=.046). But there was no correlation between S100A4 expression with multiple tumor formation and lymph node metastasis. Positive relationships were established between S100A2 expression and size (p=.041), invasiveness (p=.008) and T stage (p<.001) of papillary carcinomas. S100A4 expression was also observed more frequently in the peripheral area (p=.001).
Conclusion: These findings suggest that S100A4 and S100A2 contribute to the progression and local invasion of thyroid carcinoma.
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KEYWORD
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S100A4, S100A2, Thyroid Carcinoma, Immunohistochemistry
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